Welcome to Chow Lab Research Exploring the RNA World, One Modification at a Time
"All for One and One for All "
Our Approach
Project 1 - studying the functional roles of these modified nucleotides (m2G966 and m5C967) present in bacterial helix 31 by the combination of genetic and biochemical approaches.
Project Showcase
Name: Tek Lamichhane
e-mail: tnl@chem.wayne.edu
Webpage:
phone: 3135773090
The ribosome is a protein synthesis machine decorated with many modified nucleotides which might be important to discriminate the functional and non-functional interactions during protein synthesis. However, the detailed functional roles of these modified nucleotides are not clearly defined. Helix 31 of 16S ribosomal RNA in E. coli contains two modified nucleotides, m2G966 and m5C967. The level and types of modification at this helix (970 loop) is different between prokaryotes and eukaryotes. In collaboration with Dr. Phil Cunningham`s lab in Biological Sciences, I am studying the functional roles of these modified nucleotides (m2G966 and m5C967) present in bacterial helix 31 by the combination of genetic and biochemical approaches. We are also involved in finding potential lead compounds that can selectively bind to bacterial helix 31, but not to human analogs. Supported by NIH AI061192.
