Wayne State University

Aim Higher



College of Liberal Arts & Sciences
Department of Chemistry
Faculty Page
 
Ashok S. Bhagwat
Title Professor
Division Biochemistry
Education B.Sc., University of Bombay, 1972
M.Sc. Indian Institute of Technology, 1974
Ph.D., Pennsylvania State University, 1982
Postdoctoral Fellow, Cold Spring Harbor Laboratory, 1982-1987
Office Chem 443
Phone (313)577-2547
E-Mail
Group www.bhagwatlab.com


The research in our group is focused on the elucidating cellular mechanisms that promote or prevent mutations, and understanding how these mechanisms operate during the development of human cancers. We are particularly interested in cellular factors that increase mutations including endogenous reactive chemical species, DNA methylation, transcription, replication and human AID/APOBEC family of DNA-cytosine deaminases. Cells also contain mechanisms that counteract these potentially hazardous processes by preventing DNA damage or repairing the damage. Our goal is to understand the interplay between these opposing cellular forces to explain biological phenomena such as diversification and tailoring of antibodies against infectious agents and carcinogenesis. We take a multidisciplinary approach to understanding mutagenesis by utilizing analytical techniques such mass-spectrometry, chemical synthesis, protein and nucleic acid biochemistry, cutting-edge cellular and molecular biology methods including genomics and bioinformatics. We are also leveraging the knowledge gained by studying these mutational and DNA repair pathways in cancer cells to design, synthesize and test anticancer compounds.



REPRESENTATIVE PUBLICATIONS

*Please follow this link for the publications of the Bhagwat Group

DEPARTMENT OF CHEMISTRY ©
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5101 Cass Ave, Detroit, MI 48202
Phone: (313) 577-7784    Fax: (313) 577-8822

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