Wayne State University

Aim Higher



College of Liberal Arts & Sciences
Department of Chemistry
Faculty Page
 
Ashok S. Bhagwat
Title Professor
Division Biochemistry
Education B.Sc., University of Bombay, 1972
M.Sc. Indian Institute of Technology, 1974
Ph.D., Pennsylvania State University, 1982
Postdoctoral Fellow, Cold Spring Harbor Laboratory, 1982-1987
Office Chem 443
Phone (313)577-2547
E-Mail
Group bhagwatlab.science.wayne.edu


The research in our group is focused on elucidating cellular mechanisms that promote or prevent mutations. The cellular factors that increase mutations include generation of reactive chemical species, methylation of DNA, transcription, replication and human AID/APOBEC family of DNA-cytosine deaminases that damage DNA. Cells also express proteins that counteract these potentially hazardous processes by preventing DNA damage or repairing the damage. We aim to understand the interplay between these opposing forces to explain molecular mechanisms that allow cells to diversify and tailor antibodies to counteract infectious agents and respond to viral infections. We are also interested in explaining how these processes may also drive carcinogenesis by causing mutations and using this understanding to find anticancer treatments.



REPRESENTATIVE PUBLICATIONS

*Please follow this link for the publications of the Bhagwat Group

DEPARTMENT OF CHEMISTRY ©
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5101 Cass Ave, Detroit, MI 48202
Phone: (313) 577-7784    Fax: (313) 577-8822

image to WSU giving program link
image to WSU giving program link