Wayne State University

Aim Higher



College of Liberal Arts & Sciences
Department of Chemistry
Faculty Page
 
Jennifer L. Stockdill
Title Assistant Professor
Division Organic
Education BS Virginia Tech 2003
PhD California Institute of Technology (Stoltz) 2009
NIH Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center 2009-2012
Office Chem 277
Phone (313)577-2605
E-Mail
Group http://stockdillgroup.info


Research in the Stockdill group will be focused on the design of elegant and efficient strategies for the synthesis of complex natural products and for the synthesis and manipulation of proteins and related structures. Through these efforts, we will explore chemical reactivity and develop new reaction methods.

Target-Inspired Synthesis and Biological Studies of Natural Products

Natural products have served as inspirational targets for synthetic chemists for decades, with structural challenges driving the development of novel methods for the construction of C-C, C-N, and C-O bonds. Meanwhile, they have also been the most consistently successful source of lead targets for pharmaceutical development over the last half-century. However, many promising targets are neglected due to their apparent complexity. Our research will focus on developing rapid, convergent, and innovative approaches to these challenging structures. Subsequently, the synthetic intermediates, targets, and analogs will be tested for novel biological activity. We will then embark on studies to determine the mechanism of action of these compounds in an effort to not only provide novel potential pharmaceuticals, but also to shed light on the biological pathways involved in particular disease states.

Synthesis, Manipulation, and Biological Evaluation of Proteins and Mini-Proteins

While small molecule natural products are advantageous drug targets, owing to their stability, relative accessibility, and rigidity, peptide and protein-derived treatments offer unique benefits including their high modularity, exquisite selectivity for their cellular targets, and generally favorable toxicity profiles. Our research in this area will begin by addressing serious challenges in the synthetic accessibility of these biomolecules, such as how to control the folding of synthetic proteins. We will also develop methods for the direct functionalization of peptides and proteins, which will enable cross-linking experiments, structure-function studies, and the interrogation of protein function. Finally, synthetic analogs of medically important proteins will be generated to modify their selectivity, stability and pharmacodynamics.








REPRESENTATIVE PUBLICATIONS

Yang, Y.Y.; Ibrahim, A. A.; Hashemi, P.;* Stockdill, J. L.* Real-Time, Selective Detection of Copper(II) using Ionophore-Grafted Carbon-Fiber Microelectrodes. Anal. Chem. 2016, Accepted.

Yang, Y.Y.; Ibrahim, A. A.; Stockdill, J. L.;* Hashemi, P.* A Density-Controlled Scaffolding Strategy for Covalent Functionalization of Carbon-Fiber Microelectrodes. Anal. Methods 2015, 7, 7352-7357. Part of the 2015 Emerging Investigators Themed Collection

Stockdill, J. L.;* Lopez, A. M.; Ibrahim, A. A. Toward the ABCD Core of the Calyciphylline A-Type Daphniphyllum Alkaloids: Solvent non-Innocence in Neutral Aminyl Radical Cyclizations. Tetrahedron Lett. 2015, 3503-3506. Invited Submission to Symposium in Print in Memory of Harry Wasserman.

Ibrahim, A. A.; Golonka, A. N.; Lopez, A. M.; Stockdill, J. L.* Rapid Access to the Heterocyclic Core of the Calyciphylline A and Daphnicyclidin A-type Daphniphyllum Alkaloids via Tandem Cyclization of a Neutral Aminyl Radical. Org. Lett. 2014, 16, 1072-1075. Highlighted in Doug Taber's Organic Chemistry Highlights

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5101 Cass Ave, Detroit, MI 48202
Phone: (313) 577-7784    Fax: (313) 577-8822

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