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Philip Martin, Ph.D.
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| Title |
X-Ray Facility Manager |
| Location |
Lumigen Instrumentation Center
A. Paul Schaap Chemistry Building
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| Education |
Northern Michigan University, Chemistry, Biology, B.S. 1967
Northern Michigan University, Chemistry, M.A. 1970
Wayne State University, Biochemistry, Ph.D. 1978
Michigan State University, Post-Doctoral, 1978-1981
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| Office |
Chem 65 |
| Phone |
(313) 577-2587 |
| E-Mail |
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Dr. Martin is an expert in both small and macro-molecule X-ray crystallography. From 2001-2009, he managed the Advanced Laboratory for Macromolecular Crystallography at the Wayne State University School of Medicine. His primary responsibilities were to perform crystallography and refine enzyme structure. Through his own initiative, he developed and taught a graduate level X-Ray Crystallography course, allowing student to collect and interpret their crystal structures. Summer 2013, he will co-teach the X-Ray diffraction workshop with Dr. Ron Baird. His doctoral research earned him the DeVlieg Foundation Graduate Fellowship.
REPRESENTATIVE PUBLICATIONS
C. Purcarea, P. D. Martin, J. F. Vickery, H. I. Guy, B. F. P. Edwards, D. R. Evans, "Cloning, expression and preliminary X-ray analysis of the dihydroorotase from the hyperthermophilic bacterium Aquifex aeolicus," Acta Cryst., D58, 154-156 (2002).
B. C. Logsdon, J. F. Vickery, P. D. Martin, G. Proteasa, J. I. Koepke, S. R. Terlecky, Z. Wawrzak, M. A. Winters, T. C. Merigan, L. C. Kovari, "Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity," J.Virol., 78, 3123-3132 (2004).
P. D. Martin, C. Purcarea, P. Zhang, A. Vaishnav, S. Sadecki, H. I. Guy-Evans, D. R. Evans, B. F. Edwards, "The crystal structure of a novel, latent dihydroorotase from Aquifex aelicus at 1.7A resolution," J. Mol. Biol., 348, 535-547 (2005).
J. Ye, A. Kandegedara, P. D. Martin, B. P. Rosen, "Crystal structure of the Staphylococcus aures pI258 CadC Cd(II)/Pb(II)/Zn(II)-responsive repressor," J. Bacteriol., 187, 4217-4221 (2005).
P. D. Martin, J. F. Vickery, G. Proteasa, Y. L. Jimenez, Z. Wawrzak, M. A. Winters, T. C. Merrigan, L. C. Kovari Knisley, "Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target," Structure, 13, 1887-1895 (2005).
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