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Dr. Keith Green recently successfully defended his doctorate degree!
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Mutagenesis and Computational Studies of HDAC1 Paper Just Accepted!
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Isoform-Selective HDAC Inhibitor Review Paper Just Published!
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Dr. Pflum Recently Received Tenure!
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Residues in the 11 Å Channel of Histone Deacetylase 1 Promote Catalytic Activity: Implications for Designing Isoform-Selective Histone Deacetylase Inhibitors, Sujith V. W. Weerasinghe, Guillermina Estiu, Olaf Wiest, and Mary Kay H. Pflum, J. Med. Chem., 2008, asap. link
Isoform-selective histone deacetylase inhibitors, Anton V. Bieliauskas and Mary Kay H. Pflum, Chem. Soc. Rev., 2008, 37, 1402-1413. link
Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold, Erinprit K. Singh, Suchitra Ravula, Chung-Mao Pan, Po-Shen Pan, Robert C. Vasko, Stephanie A. Lapera, Sujith V. W. Weerasinghe, Mary Kay H. Pflum and Shelli R. McAlpine, Bioorg. Med. Chem. Lett., 2008, 18, 2549-2554. link
Histone Deacetylase 1 phosphorylation at S421 and S423 is
constitutive in vivo, but dispensable in vitro, Paulina Karwowska-Desaulniers, Anastasia Ketko, Nayana Kamath and Mary Kay H. Pflum, Biochem. Biophys. Res. Comm., 2007, 361 (2), 349-355. link
Structural Requirements of HDAC Inhibitors: SAHA Analogs Functionalized Adjacent to the Hydroxamic Acid, Anton V. Bieliauskas, Sujith V. W. Weerasinghe and Mary Kay H. Pflum, Bioorg. Med. Chem. Lett., 2007, 17 (8), 2216-2219. link
Kinase-Catalyzed Biotinylation for Phophoprotein Detection, Keith D. Green and Mary Kay H. Pflum, J. Am. Chem. Soc., 2007, 129 (1), 10-11. link
Phosphopeptide Modification and Enrichment By Oxidation-Reduction Condensation, Mangalika Warthaka, Paulina Karwowska-Desaulniers, and Mary Kay H. Pflum, ACS Chem. Biol., 2006, 1 (11), 697-701. link
Limited proteolysis of human histone deacetylase 1, Nayana Kamath, Paulina Karwowska-Desaulniers and Mary Kay H Pflum, BMC Biochemistry, 2006, 7:22. link
Cyclic AMP Response Element-Binding Protein (CREB) and CAAT/Enhancer-Binding Protein beta (C/EBPbeta) Bind Chimeric DNA Sites with High Affinity, Jamie R. Flammer, Katerina N. Popova, and Mary Kay H. Pflum, Biochemistry, 2006, 45, 9615-23. link
H-NS gives invading DNA the silent treatment, Mary Kay H. Pflum, Nat. Chem. Biol., 2006, 2, 400-401. link
Miniature DNA Binding Proteins, Mary Kay H. Pflum, Chemistry and Biology, 2004, 11, 3-4. link
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